The University of Manchester (UoM) is one of the largest single-site universities in the UK, with 40,000 students from almost every country in the world. With world-leading research and social responsibility at its heart, Manchester is a place to innovate, to lead and to make a difference. A Russell Group university, it is ranked in the top 30 universities in the world (QS World University Rankings 2019). UoM and Manchester University Foundation Trust (MFT, linked 3rd party) host the Versus Arthritis Centre for Epidemiology and the NIHR Common Disease BioResource for IMIDs. The CoInvestigators (Co-I) are part of an integrated multidisciplinary team with world-leading expertise in clinical epidemiology, digital epidemiology and neurocognitive function.