The IDEA-FAST project aims to identify novel digital endpoints to assess fatigue and sleep disturbances in neurodegenerative disorders and immune-mediated inflammatory diseases. The project’s initial investment will result in several exploitable assets that will aid key stakeholders to investigate fatigue and sleep disturbances and make use of the digital endpoints. To design an effective strategy for sustainability and exploitation, Work Package 9 aims to provide a thorough understanding of how various stakeholders can benefit from the proposed digital endpoints and ensure uptake of all other exploitable assets developed within the lifetime of the project. The present deliverable provides an initial framework for the socio-economic impact assessment and sets out the exploitation analysis framework. This work will contribute to ensuring that the exploitable assets generated within the project survive post-project funding and are consequently sustained.